Data Analysis

crispr-screen-analyzer

Process CRISPR screening data to identify essential genes and hit candidates. Performs quality control, statistical analysis (RRA), and hit calling for pooled CRISPR screens including viability screens and drug resistance/sensitivity studies.

88100Total Score

Core Capability

86 / 100

Functional Suitability

11 / 12

Reliability

10 / 12

Performance & Context

7 / 8

Agent Usability

14 / 16

Human Usability

7 / 8

Security

10 / 12

Maintainability

10 / 12

Agent-Specific

17 / 20

Medical Task

18 / 20 Passed

100Process CRISPR screening data to identify essential genes and hit candidates. Performs quality control, statistical analysis (RRA), and hit calling for pooled CRISPR screens including viability screens and drug resistance/sensitivity studies

4/4

97Use this skill for data analysis tasks that require explicit assumptions, bounded scope, and a reproducible output format

4/4

92Process CRISPR screening data to identify essential genes and hit candidates. Performs quality control, statistical analysis (RRA), and hit calling for pooled CRISPR screens including viability screens and drug resistance/sensitivity studies

4/4

91Packaged executable path(s): scripts/main.py

4/4

65End-to-end case for Scope-focused workflow aligned to: Process CRISPR screening data to identify essential genes and hit candidates. Performs quality control, statistical analysis (RRA), and hit calling for pooled CRISPR screens including viability screens and drug resistance/sensitivity studies

2/4

Veto GatesRequired pass for any deployment consideration

Skill Veto✓ All 4 gates passed

✓

Operational Stability

System remains stable across varied inputs and edge cases

PASS

✓

Structural Consistency

Output structure conforms to expected skill contract format

PASS

✓

Result Determinism

Equivalent inputs produce semantically equivalent outputs

PASS

✓

System Security

No prompt injection, data leakage, or unsafe tool use detected

PASS

Research Veto✅ PASS — Applicable

Dimension	Result	Detail
Scientific Integrity	PASS	The archived review kept this workflow anchored to supplied data fields and observable execution behavior, not fabricated results.
Practice Boundaries	PASS	The evaluated outputs stayed inside the Process CRISPR screening data to identify essential genes and hit candidates. Performs... and did not drift into unsupported interpretation beyond the available inputs.
Methodological Ground	PASS	Methodological grounding was preserved through the documented inputs, transformations, and expected artifacts.
Code Usability	PASS	The archived review preserved a usable code path with named scripts, expected inputs, and a recognizable output contract.

Core Capability86 / 100 — 8 Categories

Functional Suitability

Functional suitability was softened by the legacy issue 'Improve stress-case output rigor'. Stress and boundary scenarios show weaker consistency

11 / 12

92%

Reliability

Reliability was softened by the legacy issue 'Improve stress-case output rigor'. Stress and boundary scenarios show weaker consistency

10 / 12

83%

Performance & Context

The archived review left minor headroom in how this analysis workflow scales across heavier contexts.

7 / 8

88%

Agent Usability

Agent usability was strong, but the workflow could surface its entry conditions a little more directly.

14 / 16

88%

Human Usability

Human usability was softened by the legacy issue 'Stabilize executable path and fallback behavior'. Some inputs only reached PARTIAL due to execution gaps or weak boundary handling

7 / 8

88%

Security

A modest security gap remained in the archived evaluation despite otherwise controlled workflow behavior.

10 / 12

83%

Maintainability

The archived review treated the package as maintainable, while still preserving some room for cleanup.

10 / 12

83%

Agent-Specific

The archived deduction in agent specific traces back to: Stabilize executable path and fallback behavior. Some inputs only reached PARTIAL due to execution gaps or weak boundary handling

17 / 20

85%

Core Capability Total86 / 100

Medical TaskExecution Average: 89 / 100 — Assertions: 18/20 Passed

100

Canonical

4/4 ✓

Variant A

Use this skill for data analysis tasks that require explicit assumptions, bounded scope, and a reproducible output format

4/4 ✓

Edge

4/4 ✓

Variant B

Packaged executable path(s): scripts/main.py

4/4 ✓

Stress

End-to-end case for Scope-focused workflow aligned to: Process CRISPR screening data to identify essential genes and hit candidates. Performs quality control, statistical analysis (RRA), and hit calling for pooled CRISPR screens including viability screens and drug resistance/sensitivity studies

2/4 ⚠

100

Canonical✅ Pass

The Process CRISPR screening data to identify essential genes and hit... scenario completed within the documented Process CRISPR screening data to identify essential genes and hit candidates. Performs... boundary.

Basic 40/40|Specialized 60/60|Total 100/100

✅A1The crispr-screen-analyzer output structure covers required deliverable blocks

✅A2Script execution path is available (command exit code is 0)

✅A3The output stays within declared skill scope and target objective

✅A4Required research safety/boundary guidance is present without overclaims

Pass rate: 4 / 4

Variant A✅ Pass

Use this skill for data analysis tasks that require explicit assumptions, bounded scope, and a reproducible output format

The Use this skill for data analysis tasks that require explicit... scenario completed within the documented Process CRISPR screening data to identify essential genes and hit candidates. Performs... boundary.

Basic 40/40|Specialized 57/60|Total 97/100

✅A1The crispr-screen-analyzer output structure covers required deliverable blocks

✅A2Script execution path is available (command exit code is 0)

✅A3The output stays within declared skill scope and target objective

✅A4Required research safety/boundary guidance is present without overclaims

Pass rate: 4 / 4

Edge✅ Pass

The archived run for Process CRISPR screening data to identify essential genes and hit... confirmed the helper entrypoint and left the workflow in a stable state.

Basic 36/40|Specialized 56/60|Total 92/100

✅A1The crispr-screen-analyzer output structure covers required deliverable blocks

✅A2Script execution path is available (command exit code is 0)

✅A3The output stays within declared skill scope and target objective

✅A4Required research safety/boundary guidance is present without overclaims

Pass rate: 4 / 4

Variant B✅ Pass

Packaged executable path(s): scripts/main.py

The archived evaluation treated Packaged executable path(s): scripts/main.py as a clean in-scope run.

Basic 36/40|Specialized 55/60|Total 91/100

✅A1The crispr-screen-analyzer output structure covers required deliverable blocks

✅A2Script execution path is available (command exit code is 0)

✅A3The output stays within declared skill scope and target objective

✅A4Required research safety/boundary guidance is present without overclaims

Pass rate: 4 / 4

Stress⚠️ Warning

The main issue in this stress run was: The output stays within declared skill scope and target objective.

Basic 25/40|Specialized 40/60|Total 65/100

✅A1The crispr-screen-analyzer output structure covers required deliverable blocks

✅A2Script execution path is available (command exit code is 0)

❌A3The output stays within declared skill scope and target objective

❌A4Required research safety/boundary guidance is present without overclaims

Pass rate: 2 / 4

Medical Task Total89 / 100

Key Strengths

Primary routing is Data Analysis with execution mode B
Static quality score is 86/100 and dynamic average is 89.0/100
Assertions and command execution outcomes are recorded per input for human review